Fig. 1: CREB5 is a key target gene of ERS-related SE in HCC. | Cell Death & Disease

Fig. 1: CREB5 is a key target gene of ERS-related SE in HCC.

From: Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC

Fig. 1: CREB5 is a key target gene of ERS-related SE in HCC.

A RNA sequencing volcano mapping of TM treated or untreated HepG2 cells. B The Venn diagram of differentially expressed genes in TM treated or untreated HepG2 cells analyzed by RNA-seq and ChIP-seq. C Hockey stick plots on the basis of their input-normalized H3K27ac signals in the TM treated HepG2 cells; CREB5 is highlighted. D H3K27ac signal was significantly enriched in ERS-HepG2 cells compared with that in normal HepG2 cells. E Changes in BRD4 protein levels in HepG2 cells treated with different concentrations of JQ1. Changes in the mRNA (F) and protein (G) levels of BRD4 and CREB5 in HepG2 cells treated with 2.5 µM TM and different concentrations of JQ1. H Three sgRNAs were designed to target specific regions of SEs. I The blockade of three individual constituent sites on the SEs affects CREB5 transcription levels.

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