Fig. 7: Triple combined treatment of NCT-503, perhexiline, and ALPI3MT55 in vivo.
From: PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma
A Tumor growth curve of xenografted U2OS cells treated with NCT-503, ALPI3MT55, combination of NCT-503 and ALPI3MT55, or vehicle. B Body weight of xenografted mice with the treatment in (A). C PHGDH expression in UTSW2035 PDX and its isolated cells. D Cell death percentage of cells isolated from OS PDXs with the triple combined treatment of NCT-503, perhexiline, and ALPI3MT55 in vitro. E Tumor growth of the UTSW2035 PDX treated with NCT-503, perhexiline, and ALPI3MT55 in vivo. F Body weight of PDX tumor implanted mice. G Schematic model of apoptotic cell death induction by NCT-503, perhexiline, and ALPI3MT55. Bars represent means of values; error bars represent SEM. *P < 0.05, **P < 0.01, ***p < 0.00 5, ****p < 0.001.
