Fig. 4: TIGIT as a potential surface marker for T cell exhaustion in ECCA. | Cell Death & Disease

Fig. 4: TIGIT as a potential surface marker for T cell exhaustion in ECCA.

From: TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy

Fig. 4: TIGIT as a potential surface marker for T cell exhaustion in ECCA.

A and B Flow cytometric analysis of immunological checkpoint PD-1 expression in TIGIF-CD8+ and TIGIF+CD8+T cell subsets. C and D Flow cytometric analysis of immunological checkpoint TIM-3 expression in TIGIF−CD8+ and TIGIF+CD8+T cell subsets. E and F Flow cytometric analysis of the cytokine IFN-α expression in TIGIF-CD8+ and TIGIF+CD8+T cell subsets. G and H Flow cytometric analysis of the cytokine TNF-γ expression in TIGIF−CD8+ and TIGIF+CD8+T cell subsets. TIGIF-CD8+ and TIGIF+CD8+T cell subset levels were compared by paired Student’s t-test, n = 26, *P < 0.05, **P < 0.01, P < 0.001***.

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