Fig. 8: UCP2 modulates AMPK activity, influencing the Nrf2-HO-1 pathway. | Cell Death & Disease

Fig. 8: UCP2 modulates AMPK activity, influencing the Nrf2-HO-1 pathway.

From: Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases

Fig. 8

A, B The protein expression levels of p-AMPK in N2a cells. C, D The protein expression levels of Nrf2, HO-1 and Keap1 in N2a cells. E, F The Nrf2 protein expression in cytosolic and mitochondrial extracts in N2a cells. G, H Western blot analysis of Nrf2 protein expression in N2a cells treated with PrP106–126, irisin, MG132 (proteasome inhibitor), Compound C (AMPK inhibitor), or AICAR (AMPK activator). The data are presented as the means ± SDs (n = 6), *P < 0.05; **P < 0.01; ***P < 0.001.

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