Fig. 4: CXCL7 facilitates the proliferation, migration and invasion of MM cells. | Cell Death & Disease

Fig. 4: CXCL7 facilitates the proliferation, migration and invasion of MM cells.

From: Myeloma cell-derived CXCL7 facilitates proliferation of tumor cells and occurrence of osteolytic lesions through JAK/STAT3 pathway

Fig. 4

A. The expression level of CXCL7 in MM cell lines within the CCLE database. The expression level of CXCL7 in the CXCL7-OE and NC H929 (B)/RPMI 8226 (C) cell lines was evaluated via qPCR. The expression level of CXCL7 in the CXCL7-KD and NC U266(D)/RPMI 8226 (E) cell lines was evaluated via qPCR. Western blot analysis of the expression level of CXCL7 protein in the CXCL7-OE and NC H929(F)/RPMI8226 (G) cell lines. Western blot analysis of the expression level of CXCL7 protein in the CXCL7-KD and NC U266 (H)/RPMI8226 (I) cell lines. ELISA was utilized to assess the levels of CXCL7 extracellular secreted protein in the CXCCL7-OE and NC H929 (J)/RPMI8226 (K) cell lines. ELISA was utilized to assess the levels of CXCL7 extracellular secreted protein in the CXCCL7-KD and NC U266 (L)/RPMI8226 (M) cell lines. N–Q The CCK8 assay was employed to assess the differences in cell proliferation rates among CXCL7-OE, CXCL7-KD, and NC group. R, S Subcutaneous xenograft tumors of mice in CXCL7-OE group and NC group. T The mean growth rate of subcutaneous xenograft tumors in CXCL7-OE and NC mice. U The expression levels of CXCL7 and Ki-67 in the subcutaneous xenograft tumors of the CXCL7-OE group and NC group (via immunohistochemical).

Back to article page