Fig. 1: Overview of the glycolytic metabolic pathway in tumour growth.
From: “Friends or foes”: a new perspective of tumour metabolic transcriptional modification
Tumour tissue is often accompanied by abnormal blood vessel growth to supply more energy. Free glucose is taken up by cells from the tumour microenvironment and is ultimately converted into lactate through the catalysis of key enzymes such as HK2, PFK1, and PK, causing the further acidification of the tumour microenvironment. Abnormal blood vessel growth leads to hyperactivation of glycolytic function in tumours, further producing more ATP and metabolic byproducts that promote angiogenesis. This figure is created with BioRender.com.
