Fig. 2: Cooperative and inhibitory networks of transcriptional regulation in tumour glycolysis.
From: “Friends or foes”: a new perspective of tumour metabolic transcriptional modification
The regulatory effects of transcription factors on glycolysis in tumour cells are very complex. One transcription factor can regulate the expression of multiple target genes, and the functions of different transcription factors synergistically promote or antagonize each other. In addition, the targets of classical transcription factors (such as HIF-1α, MYC, p53, E2F1, and p53) are complex and often involve multiple key enzymes. However, some recently discovered transcription factors (such as SALL4, ATOH8, SMAD4, and MZF1) have relatively few, even single, targets, and the specific mechanism remains to be elucidated. This figure is created with BioRender.com.
