Fig. 2: CDK6 binds to promoters of OXPHOS genes.
From: CDK6 kinase inhibition unmasks metabolic dependencies in BCR::ABL1+ leukemia
A Venn diagram showing the overlap of CDK6-ChIP sequencing peaks of BCR::ABL1+ HA-Cdk6 and HA-Cdk6K43M cell lines; n = 2 per condition. B Venn diagram showing the overlap of ChIP-seq peaks and open chromatin regions from ATAC-seq of wildtype CDK6 and kinase inactive CDK6; n = 2 per genotype. C Top 10 hits from a transcription factor motif analysis of overlapping chromatin regions from ChIP-seq and ATAC-seq. D Venn diagram showing the overlap of genes from the HALLMARK OXPHOS gene set (n = 177) and differentially expressed genes from RNA-seq, genes harboring a CDK6 ChIP-seq or/and an NRF-1 ChIP-seq peak.
