Fig. 6: Combined inhibition of CDK6 and glycolysis increases apoptosis in CML.
From: CDK6 kinase inhibition unmasks metabolic dependencies in BCR::ABL1+ leukemia
A Cdk6 expression (variance of standard transformed expression values) in patient samples with different stages of CML and healthy control samples. Control (Ctrl) n = 8, chronic/accelerated phase (CP/AP) n = 30, blast crisis (BC) n = 7. **p ≤ 0.01, ****p ≤ 0.0001. AnnexinV/7AAD stainings of human K562 (B) and AR230 (C) CML cells on day 13 and AR230R (D) on day 11 of proliferation experiments (see Supplementary Fig. S6A, B, E); n = 4 replicates. Data are depicted as mean ± SD; ****p ≤ 0.0001.
