Fig. 2: Low expression of SERPING1 was correlated with the poor prognosis of LUAD patients and proliferation pathways.
From: WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway
A Comparison of distinct clinical features distribution in the SERPING1-high and low group from TCGA database. Kaplan-Meier curves of survival for SERPING1-high and low group from (B) GSE68465 (n = 442) and (C) multicohort study (n = 2166). D Forest plot of HR of SERPING1 expression and the prognosis of LUAD patients. E ROC curve of the predictive ability of SERPING1 expression level for LUAD diagnosis. F Heatmap of DEGs after overexpression of SERPING1 by RNA-seq. G KEGG analysis of DEGs; FDR < 0.05 was considered as significantly enriched. H Reconstructed developmental trajectory of tumor cells showing pseudotime colored from blue to yellow. I Heatmap showing expression of top 50 identified genes across single cells. The color key from blue to red indicates relative expression levels from low levels to high levels. J Expression patterns scatter plot of AHNAK2 and SERPING1 through pseudotime.
