Fig. 1: BAP1 mRNA level was upregulated in human HCC with more aggressive tumor behavior. | Cell Death & Disease

Fig. 1: BAP1 mRNA level was upregulated in human HCC with more aggressive tumor behavior.

From: Nuclear localization of BRCA1-associated protein 1 is important in suppressing hepatocellular carcinoma metastasis via CTCF and NRF1/OGT axis

Fig. 1: BAP1 mRNA level was upregulated in human HCC with more aggressive tumor behavior.

A BAP1 mRNA expression in HCC tumor tissues and non-tumorous liver tissues in TCGA-LIHC (n = 50) and our in-house HCC (n = 41) cohorts. T: Tumor tissue, NT: Non-tumorous liver tissue. (***P < 0.001, Student’s t-test). B BAP1 mRNA expression in tumors and corresponding non-tumorous livers by qRT-PCR in in-house HCC cohort (n = 124). 35.5% of the tumors showed ≥2-fold upregulation. C Clinicopathological correlation of BAP1 mRNA expression in human HCCs. D Upregulation of BAP1 mRNA expression in different stages of HCC. (***P < 0.001, Student’s t-test) E Overall survival analysis of HCC patients with high or low BAP1 expression in TCGA-LIHC cohort. (*P < 0.05, Log rank test).

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