Fig. 4: RHOJ was suppressed upon BAP1 knockdown in HepG2 cells. | Cell Death & Disease

Fig. 4: RHOJ was suppressed upon BAP1 knockdown in HepG2 cells.

From: Nuclear localization of BRCA1-associated protein 1 is important in suppressing hepatocellular carcinoma metastasis via CTCF and NRF1/OGT axis

Fig. 4: RHOJ was suppressed upon BAP1 knockdown in HepG2 cells.

A Transcriptome analysis of BAP1 knockdown in HepG2 cells. A total of 185 genes were upregulated (left panel) and 222 genes downregulated (right panel) upon BAP1 knockdown in HepG2 cells. B Transcriptome expression level changes of Rho protein family upon knockdown of BAP1 in HepG2 cells (left panel). RHOJ expression level in HepG2 cells with BAP1 knockdown (right panel). C Cell migration assay upon overexpression of RHOJ in HepG2 cells (n = 3). Scale bar, 100 μm. (*P < 0.05, Student’s t-test). D Overexpression of RHOJ in shBAP1 HepG2 cells resulted in significantly reduced cell migratory ability as compared with the shBAP1#1 cells (n = 3). Scale bar, 100 μm. (*P < 0.05, **P < 0.01, Student’s t-test).

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