Table 2 Ectopic expression of protumorigenic chemokine receptors.
From: CAR-T therapy dilemma and innovative design strategies for next generation
Chemokine-receptor | Mechanisms | Targets | Refs |
|---|---|---|---|
CXCL8-CXCR1/2 | Co-expression of the matched chemokine receptor CXCR2 in CAR T-cells results in increased migration | Integrin αvβ6 | [51] |
Hepatocellular carcinoma tumors express high level of CXCR2 ligands and CXCR2 expression endowed CAR-T cells with improved trafficking ability and enhanced tumor accumulation | Glypican-3 | [117] | |
Radiation-induced CKCL8 release from the tumor can enhance intratumoral CXCR1 or CXCR2 modified CAR-T cells trafficking | CD70 | [52] | |
CCL2-CCR2 | High concentration of CCL2 recruits CCR2 expressing CAR-T cells | Mesothelin | [53] |
