Fig. 4: Agonistic and antagonistic regulation of the receptor differentially alters the expression of adhesion molecules in wild type and GABAα1-knock-in animals. | Cell Death & Disease

Fig. 4: Agonistic and antagonistic regulation of the receptor differentially alters the expression of adhesion molecules in wild type and GABAα1-knock-in animals.

From: Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors

Fig. 4

A Schematic representation of the individual steps of neutrophil migration with the associated adhesion molecules L-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), very late antigen-4 (VLA-4), lymphocyte function-associated antigen-1 (LFA-1), intercellular adhesion molecule-1/2 (ICAM-1/2) and cluster of differentiation 99 (CD99). Created with biorender.com. B–E The mean fluorescence intensity of the measured adhesion molecules was quantified by flow cytometry. Blood, lung, and BAL from wild type and GABAα1-Knock-in animals were analyzed 24 hours after inducing inflammation by LPS. The following were examined: B CD62L, C PSGL-1, D CD49d, and E LFA-1. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA and Bonferroni correction was used for multiple group comparison.

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