Fig. 5: Release of inflammatory mediators is changed by modulation of the GABAA-receptor. | Cell Death & Disease

Fig. 5: Release of inflammatory mediators is changed by modulation of the GABAA-receptor.

From: Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors

Fig. 5

The release of cytokines was quantified by enzyme-linked immunosorbent assay (ELISA). The samples used were the supernatants of BAL from wild type and GABAα1-Knock-in animals, 3 hours after LPS inhalation (n ≥ 6). The investigations focused on the two proinflammatory cytokines (A) tumor necrosis factor α (TNFα) and (B) interleukin-6 (IL-6), as well as the chemokines (C) keratinocyte-derived chemokine (CXCL1/KC) and (D) CXCL2/3/MIP-2 macrophage inflammatory protein-2 (CXCL2/3/MIP-2). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA and Bonferroni correction was used for multiple group comparison.

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