Fig. 4: The expression of β-catenin and PPAT is strongly correlated in HB. | Cell Death & Disease

Fig. 4: The expression of β-catenin and PPAT is strongly correlated in HB.

From: Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma

Fig. 4: The expression of β-catenin and PPAT is strongly correlated in HB.

A GSEA evaluating gene signature of Wnt/β-catenin signaling in paired HB and normal tissues (n = 10). NES normalized enrichment score. B Relative mRNA levels of CTNNB1 in paired HB and normal tissues (n = 18) were determined by RT-qPCR (paired t-test). C Scatter plots revealed a positive correlation between PPAT and CTNNB1 expression in HB tissues detected by RT-qPCR. The linear best fit lines were shown. The Pearson correlation coefficient (r) and p values (p) were obtained from two-tailed t-test. D–F Scatter plots revealed a positive correlation between PPAT and CTNNB1 expression in HB tissues. Data were from three independent published datasets. The linear best fit lines were shown. The Pearson correlation coefficient (r) and p values (p) were obtained from two-tailed t-test. G Representative IHC analysis of PPAT and β-catenin in paired HB and normal tissues. H The expression of PPAT in HB harboring WT and mutant CTNNB1. Data were from an independent published dataset (unpaired t-test).

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