Fig. 9: Schematic diagram illustrates the impact of HRH1 on the growth and lymph node (LN) metastasis of OSCC cells, along with their underlying mechanisms (created with BioRender.com). | Cell Death & Disease

Fig. 9: Schematic diagram illustrates the impact of HRH1 on the growth and lymph node (LN) metastasis of OSCC cells, along with their underlying mechanisms (created with BioRender.com).

From: Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma

Fig. 9

Left panel: HRH1 activation initiates PKC and NF-κB activation, subsequently prompting ADAM9-mediated upregulation of activated TGF-β and the Snail family, thereby inducing EMT-mediated OSCC progression. Cyclical increases in the HRH1-ADAM9-Snail/Slug axis contribute to the aggravation of EMT and OSCC growth and LN metastasis. Right panel: Activated STAT3 might act as a compensatory pathway in response to HRH1 signaling blockade in OSCC cells. A combined approach targeting both HRH1 and STAT3 using inhibitors or shRNAs presents a promising strategy for impeding EMT-mediated OSCC progression. PKC protein kinase C, NF-κB nuclear factor kappa B.

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