Fig. 2: Inhibition of MCI induces ferroptosis. | Cell Death & Disease

Fig. 2: Inhibition of MCI induces ferroptosis.

From: Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer

Fig. 2: Inhibition of MCI induces ferroptosis.The alternative text for this image may have been generated using AI.

a Lipid peroxidation levels in Huh7 or NCI-H23 cells treated with ROT (50 μM), following pretreatment with Ferrostatin-1 (Fer-1; 10 μM) or Z-VAD-FMK (ZVF; 10 μM). b Cell viability in Huh7 or NCI-H23 cells treated with ROT (50 μM) after pretreatment with Fer-1 (10 μM) or ZVF(10 μM). c Cell viability in Huh7 or NCI-H23 cells treated with IACS-010759(IACS ;50 μM) after pretreatment with Fer-1 (10 μM) or ZVF (10 μM). d Mitochondrial morphology observed by transmission electron microscopy in Huh7 cells treated with ROT (50 μM) or IACS (50 μM) after pretreatment with Fer-1 (10 μM). e Protein levels of GPX4 in different cancer cell. f Lipid peroxidation levels in SKOV3 cells treated with ROT (50 μM) or RSL3(0.5 μM), following pretreatment with Fer-1(10 μM).

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