Fig. 2: EphA7 demethylation inhibited CC progression via the PI3K/AKT signaling pathway. | Cell Death & Disease

Fig. 2: EphA7 demethylation inhibited CC progression via the PI3K/AKT signaling pathway.

From: Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer

Fig. 2

A These DEGs were obtained by comparing normal cervical samples with high EphA7 expression (n = 5) to CC samples with low EphA7 expression (n = 5) on the basis of EphA7 RNA-seq data (GSE9750). KEGG pathway enrichment analysis revealed that EphA7 significantly altered the PI3K/AKT signaling pathway. B Signaling pathways regulated by EphA7 according to the DAVID web tool. C The levels of the phosphorylated forms of PI3K and AKT were reduced, and the pPI3K/PI3K and pAKT/AKT ratios were decreased (P < 0.05) in the EphA7 demethylation group (n = 3). D The expression of EFNA5 and EphA2 was increased in the EphA7 demethylation group (n = 3). Error bars represent the means ± SDs, P values were calculated using two-tailed unpaired Student’s t tests (C, D). *P < 0.05,  **P < 0.01, ***P < 0.001 and ns, not significant.

Back to article page