Fig. 8: Independent or combined regulation of TRMT10A and tRF-22 expression effectively inhibits VM formation and tumor growth in orthotopic xenografts in nude mice. | Cell Death & Disease

Fig. 8: Independent or combined regulation of TRMT10A and tRF-22 expression effectively inhibits VM formation and tumor growth in orthotopic xenografts in nude mice.

From: TRMT10A regulates tRNA-ArgCCT m1G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma

Fig. 8: Independent or combined regulation of TRMT10A and tRF-22 expression effectively inhibits VM formation and tumor growth in orthotopic xenografts in nude mice.The alternative text for this image may have been generated using AI.

Immunohistochemical staining for TRMT10A, MXD1, and HIF-1α (A), as well as FISH staining for tRF-22 (B), in glioma samples. Data are presented as mean ± SD (n = 5). *P < 0.05, **P < 0.01 compared to the OE-NC + sh-NC group; ##P < 0.01 compared to the OE-TRMT10A group; &P < 0.05, &&P < 0.01 compared to the sh-tRF-22 group. Scale bar for IHC staining = 200 μm, Scale bar for FISH staining = 100 μm. C Schematic diagram of the TRMT10A/tRF-22/MXD1 pathway regulating VM formation in GBM.

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