Fig. 1: METTL3 is upregulated in pancreatic cancer. | Cell Death & Disease

Fig. 1: METTL3 is upregulated in pancreatic cancer.

From: TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy

Fig. 1

A, B METTL3 expression between pancreatic cancer tissues and normal tissues in GEO database. C The protein expression of METTL3 in cell lines was detected by western blotting. D–F Representative images of METTL3 IHC staining in paired pancreatic cancer and adjacent normal tissues with different malignancy histologic grades (G1–G3). Scale bars, 100 μm. G The degree of METTL3 immunohistochemical staining was evaluated in pancreatic cancer and adjacent normal tissues according to the immunoreactive score (IRS). H IRS of METTL3 IHC staining in tumors with different malignancy histological grades (G1–G3). I Kaplan–Meier survival plots (log-rank test, P values displayed) demonstrated the prognostic impact of METTL3 expression in pancreatic cancer. J Kaplan–Meier survival plots exhibited the effect of METTL3 expression on the prognosis of pancreatic cancer in GEO database GSE183795. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).

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