Table 4 Association of SERPINA3 within 72 hours with modified Rankin scale at different follow-up times in ICH patients.

From: SERPINA3 predicts long-term neurological outcomes and mortality in patients with intracerebral hemorrhage

 

Adjustment for the time from stroke to blood collection

Adjustment for the time from stroke to blood collection, age, sex, current smoking, hypertension, cerebrovascular disease history, and diabetes

Adjustment for NIHSS at blood collection, age, sex, current smoking, hypertension, cerebrovascular disease history, and diabetes

Adjustment for the ABC/2, age, sex, current smoking, hypertension, cerebrovascular disease history, and diabetes

Adjustment for the NIHSS at blood collection, ABC/2, age, sex, current smoking, hypertension, cerebrovascular disease history, and diabetes

Follow-up time

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

1 month

1.32 (1.14, 1.53)

<0.001

1.28 (1.10, 1.49)

0.002

1.24 (1.04, 1.47)

0.014

1.18 (1.00, 1.38)

0.051

1.18 (0.98, 1.43)

0.084

3 months

1.34 (1.18, 1.52)

<0.001

1.32 (1.15, 1.50)

<0.001

1.29 (1.11, 1.50)

0.001

1.21 (1.05, 1.40)

0.009

1.22 (1.03, 1.43)

0.020

6 months

1.46 (1.28, 1.66)

<0.001

1.43 (1.25, 1.64)

<0.001

1.43 (1.23, 1.66)

<0.001

1.46 (1.25, 1.70)

<0.001

1.41 (1.18, 1.68)

0.005

12 months

1.55 (1.35, 1.78)

<0.001

1.53 (1.32, 1.76)

<0.001

1.51 (1.29, 1.77)

<0.001

1.54 (1.28, 1.85)

<0.001

1.55 (1.27, 1.89)

<0.001

  1. CI confidence interval. Odds ratios, 95% CIs, and p-values resulting from binary logistic regression models. ORs were interpreted as multiplicative increases in the odds of a modified Rankin Scale score ≥ 3 for each fold increase in SERPINA3 concentrations. The complete multivariable analysis was adjusted for the time from stroke to blood collection, age, sex, current smoking, hypertension, cerebrovascular disease, and diabetes. The bleeding volume of intravascular hemolysis (IVH) was calculated using a 3D slicer. mRS modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale, GCS Glasgow Coma Score.
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