Fig. 9: Noxa expression induces cleaved caspase 3 in MN9D cells. | Cell Death & Disease

Fig. 9: Noxa expression induces cleaved caspase 3 in MN9D cells.

From: The absence of Pitx3 results in postnatal loss of dopamine neurons and is associated with an increase in the pro-apoptotic Bcl2 factor Noxa and cleaved caspase 3

Fig. 9

Titration of different Noxa concentrations into dopaminergic MN9D cells together with a small amount (100 ng) of EV-mCherry. It is assumed that all mCherry-positive cells also have Noxa transfected. Moreover, MN9D cells do not express Noxa endogenously. Starting from 250 ng Noxa, levels of the apoptosis marker CC3 increase while mCherry levels decrease. This suggests that the introduction of Noxa into MN9D cells induces apoptosis in a dose-dependent manner. **p < 0.01, ***p <  0.001, n = 3.

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