Fig. 7: DEC1 promotes EMT and CDDP resistance by targeting ZEB1. | Cell Death & Disease

Fig. 7: DEC1 promotes EMT and CDDP resistance by targeting ZEB1.

From: GLI2 inhibits cisplatin sensitivity in gastric cancer through DEC1/ZEB1 mediated EMT

Fig. 7: DEC1 promotes EMT and CDDP resistance by targeting ZEB1.

A Western blot analysis investigated the effect of DEC1 and ZEB1 joint regulation on ZEB1, N-cadherin, Vimentin, Snail1 expressions. B–E The effect of DEC1 and ZEB1 on the migration of GC cells was analyzed by transwell assay and wound healing assay. Scale bars:200 µm. F CCK-8 experiment shows the IC50 values for CDDP with DEC1 and ZEB1 co-expression alteration in GC cells. ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05.

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