Fig. 3: BECN1 was involved in ESM1 regulation of lipid metabolism in OC cells. | Cell Death & Disease

Fig. 3: BECN1 was involved in ESM1 regulation of lipid metabolism in OC cells.

From: IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming

Fig. 3

A Western blot was utilized to verify the overexpression efficiency of ESM1 and BECN1. B Western blot analysis of FASN, SCD1, HMGCS1, HMGCR, CD36, and ACOX1 levels in OC cells. C The content of neutral lipids in OC cells was observed by BODIPY 493/503 staining. The white arrows point to the locations where neutral lipid droplets accumulate. Scale bar, 25 μm. D Biochemical kits were utilized to analyze the contents of TG, NEFA, and TC in OC cells. #p < 0.05 vs. oe-NC. %p < 0.05 vs. oe-ESM1+oe-NC.

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