Fig. 2: EZH2i change the metabolic profile of ACC cells. | Cell Death & Disease

Fig. 2: EZH2i change the metabolic profile of ACC cells.

From: A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis

Fig. 2: EZH2i change the metabolic profile of ACC cells.The alternative text for this image may have been generated using AI.

A, B Heatmap for mRNA expression of lipid metabolism genes in H295R cells after 48 h of GSK126 treatment. Data were the values from three separate RNA samples presented as log10 of fold change. LDs lipid droplets; FAO fatty acids oxidation, TF transcription factors. C–K QPCR graphs and western blots of representative genes from (A) (n = 3, means ± SEM *p < 0.05; **p < 0.01; ****p <0.0001). L Untargeted metabolomics analysis was performed on H295R cells treated with GSK126 (5 and 25 µM) for 48 h. Venn diagram represents statistically significant differentially abundant metabolites across 5 and 25 µM GSK126-treated cells. M Pie chart depicting the proportions of metabolite classes in the 108 common metabolites. N Schematic representation of linoleic acid oxidation pathways.

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