Fig. 6: Tazemetostat combined with ferroptosis inducers is an effective treatment for different tumor types. | Cell Death & Disease

Fig. 6: Tazemetostat combined with ferroptosis inducers is an effective treatment for different tumor types.

From: A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis

Fig. 6

A–C mRNA expression of GPX4 and SLC7A11 in cell lines from different tumor types treated for 48 h with tazemetostat (TAZ 5 µM). D–F Cell viability of tumor cell lines treated for 48 h with TAZ (5 μM) and RSL3 (1 µM, for the last 4 h) and their combinations. G–I Representative images of explanted MDA-MB231 xenografts (G) and relative graphs of tumor volume (H) and weight (I). J, K mRNA expression of GPX4 and SLC7A11 in xenografts tumor samples. L Protein expression and relative quantification of GPX4 in tumor samples. Data were expressed as means ± SEM. *p < 0.05; **p < 0.01, ***p < 0.001;  ****p < 0.0001.

Back to article page