Fig. 6: Tazemetostat combined with ferroptosis inducers is an effective treatment for different tumor types. | Cell Death & Disease

Fig. 6: Tazemetostat combined with ferroptosis inducers is an effective treatment for different tumor types.

From: A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis

Fig. 6: Tazemetostat combined with ferroptosis inducers is an effective treatment for different tumor types.The alternative text for this image may have been generated using AI.

A–C mRNA expression of GPX4 and SLC7A11 in cell lines from different tumor types treated for 48 h with tazemetostat (TAZ 5 µM). D–F Cell viability of tumor cell lines treated for 48 h with TAZ (5 μM) and RSL3 (1 µM, for the last 4 h) and their combinations. G–I Representative images of explanted MDA-MB231 xenografts (G) and relative graphs of tumor volume (H) and weight (I). J, K mRNA expression of GPX4 and SLC7A11 in xenografts tumor samples. L Protein expression and relative quantification of GPX4 in tumor samples. Data were expressed as means ± SEM. *p < 0.05; **p < 0.01, ***p < 0.001;  ****p < 0.0001.

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