Fig. 8: MMP1 inhibition enhances SG-induced cell death. | Cell Death & Disease

Fig. 8: MMP1 inhibition enhances SG-induced cell death.

From: MMP1-induced NF-κB activation promotes epithelial–mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancer

Fig. 8: MMP1 inhibition enhances SG-induced cell death.The alternative text for this image may have been generated using AI.

a, b Comparison of apoptotic cell number between MMP1-knockdown and negative control with or without SG treatment in resistant cell lines via Tunnel assays. c, d Comparison of apoptotic cell number between MMP1-knockdown and negative control with or without SG treatment in resistant cell lines via Annexin V-PI assays. e Proposed mechanisms of MMP1-mediated SG resistance in HR + BC.

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