Fig. 6: Histological and immunoblot analyses enhanced induction of necroptosis in Gsdmd−/− mice within CaOx crystal-induced chronic nephropathy. | Cell Death & Disease

Fig. 6: Histological and immunoblot analyses enhanced induction of necroptosis in Gsdmd−/− mice within CaOx crystal-induced chronic nephropathy.

From: Gasdermin D deficiency aggravates nephrocalcinosis-related chronic kidney disease with rendering macrophages vulnerable to necroptosis

Fig. 6

A Representative images of pMLKL staining in kidneys from WT mice fed a control diet, and of WT and Gsdmd−/− mice fed an oxalate-rich diet. The bottom panels show higher magnification views of the regions outlined by dotted rectangles in the top panels. B Quantification of pMLKL-positive areas. Data are presented as mean ± SE. P values are calculated using one-way ANOVA with Turkey’s post-hoc test. ***P < 0.001.

Back to article page