Fig. 3: IEC-specific Rap2B deletion inhibits the progression of colitis.

A Schematic of the experimental strategy to induce colitis model. B–D Quantification of the relative body weight, rectal bleeding and diarrhea of Rap2B^IEC-WT and Rap2B^IEC-KO mice with colitis model induction (n = 8). E, F Representative H&E analysis and clinical score of the colons from Rap2B^IEC-WT (n = 8) and Rap2B^IEC-KO (n = 6) mice with colitis model induction. G, H Representative micrographs of immunochemistry staining for Ki-67 and quantitative analysis in tumors from Rap2B^IEC-WT and Rap2B^IEC-KO mice with colitis model induction (n = 4; 2 images/mice). I, J Representative micrographs of immunochemistry staining for F4/80 and quantitative analysis in tumors from Rap2B^IEC-WT and Rap2B^IEC-KO mice with colitis model induction (n = 4). K, L Representative micrographs of immunochemistry staining for S100A9 and quantitative analysis in tumors from Rap2B^IEC-WT and Rap2B^IEC-KO mice with colitis model induction (n = 4; 2 images/mice). Data in J, L and N are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed unpaired t test.