Fig. 5: PGC1α expression and activity inversely correlate with SRM in prostate cancer patients and has prognostic value. | Cell Death & Disease

Fig. 5: PGC1α expression and activity inversely correlate with SRM in prostate cancer patients and has prognostic value.

From: Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer

Fig. 5

A Analysis of SRM mRNA in PCa patients stratified according to the mean expression of PGC1α mRNA (PPARGC1A). B Correlation analysis between PPARGC1A and SRM mRNA expression in primary tumor specimens of different prostate cancer datasets. C Association of the combined expression of PPARGC1A and SRM mRNA with disease-free survival (DFS) in human PCa specimens. Patients were grouped according to the average mRNA expression of both genes. H: high, above average. L: low, below average. Four groups were generated: PGC1α H - SRM L, PGC1α L - SRM H, PGC1α H - SRM H and PGC1α L - SRM L. Sample sizes: Grasso, n = 45; Taylor, n = 131; Glinsky, n = 79 and TCGA provisional, n = 497. Statistics: Mann Whitney test (A) Spearman correlation Rho/ρ (B), Log-rank (Mantel–Cox) test (C). *p.value < 0.05; **p.value < 0.01; ***p.value < 0.001. Error bars indicate s.e.m. HR harzard ratio, p.v p-value.

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