Fig. 4: GBM zebrafish model shows increased purine biosynthesis and reduced purine catabolism. | Cell Death & Disease

Fig. 4: GBM zebrafish model shows increased purine biosynthesis and reduced purine catabolism.

From: Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment

Fig. 4

a RNA-seq analysis of the top 50 GO pathways dysregulated in the zic:RAS zebrafish model. Data are shown as −log10 of FDR. b Summary plot of genes involved in purine dysregulated pathways showed in (a) with the description of their functions. In red are represented functions correlated with biosynthetic processes and in blue functions correlated with catabolic processes. Squares are key-coloured according to their log2 FC over CTRL. CTRL control, FC fold change, FDR false discovery rate, GO gene ontology.

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