Fig. 1: AT-SIRT3OE improves insulin sensitivity independent of adiposity in HFD-fed obese mice. | Cell Death & Disease

Fig. 1: AT-SIRT3OE improves insulin sensitivity independent of adiposity in HFD-fed obese mice.

From: Adipocyte-expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages

Fig. 1

A The protein expression of SIRT3 in eWAT, iWAT and the liver from AT-NC and AT-SIRT3OE mice. n = 4 independent experiments. B Body weight of mice with RD or HFD feeding. n = 6 mice per group. C Organ index of eWAT, iWAT, the liver and BAT (organ index = organ weight/body weight × 100%). n = 6 mice per group. D Fasting blood glucose level. n = 6 mice per group. E Serum insulin level after 16 h fasting. n = 6 mice per group. F The HOMA-IR index. n = 6 mice per group. G Glucose tolerance tests after 11 weeks of RD or HFD feeding and AUC (area under curve) of GTTs. n = 6 mice per group. H Insulin tolerance tests after 12 weeks of RD or HFD feeding and AUC of ITTs. n = 8 mice per group. Data are expressed as means ± SEM. #p < 0.05, ##p < 0.01, ###p < 0.001, HFD-AT-NC vs. RD-AT-NC; *p < 0.05, **p < 0.01, AT-NC vs. AT-SIRT3OE.

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