Fig. 8: Exogenous PC and LC regulate FAO in BMDMs. | Cell Death & Disease

Fig. 8: Exogenous PC and LC regulate FAO in BMDMs.

From: Adipocyte-expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages

Fig. 8

DMDMs were cultured in the presence or absence of LC for 12 h. FAO dependency (A), flexibility (B) and capacity (C) were analyzed by Seahorse mitochondrial fuel flex test. $P < 0.05, LPS vs. control. $$P < 0.01, LPS vs. control. *P < 0.05, LPS vs. LPS + LC. DMDMs were cultured in the presence or absence of PC 12 h. FAO dependency (D), flexibility (E) and capacity (F) were analyzed by Seahorse mitochondrial fuel flex test. n = 3 replicates. Data are expressed as means ± SEM. ##P < 0.01, IL-4 vs. control, **P < 0.01, IL-4 vs. IL-4 + PC, ***P < 0.001, IL-4 vs. IL-4 + PC.

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