Fig. 5: Knockdown of Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) inhibited subcutaneous tumorigenesis, lung metastasis, and liver metastasis of papillary thyroid cancer (PTC) cells. | Cell Death & Disease

Fig. 5: Knockdown of Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) inhibited subcutaneous tumorigenesis, lung metastasis, and liver metastasis of papillary thyroid cancer (PTC) cells.

From: Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway

Fig. 5

Images (A), weight (B), and volume (C) of subcutaneous tumors in mice on day 30 after subcutaneous injection of TPC-1-shNC cells and TPC-1-shP4HA2 cells. D Representative images of hematoxylin and eosin (H&E) staining and immunohistochemical staining (P4HA2 and Ki67) of subcutaneous tumors in the mice. The scalebar represents 50 μm. Images of mouse lungs (E) and livers (F) on day 30th after injection of BCPAP-shNC cells and BCPAP-shP4HA2 cells in the mice tail vein. G Representative images of H&E staining and immunohistochemical staining (P4HA2 and Ki67) of metastatic tumors in the lungs of experimental mice. The scalebar represents 50 μm. Fluorescent images of mouse lungs (H) and livers (I) after injection of BCPAP-shNC cells and BCPAP-shP4HA2 cells in the tail vein. The green spots in the figure indicate BCPAP-shNC cells or BCPAP-shP4HA2 cells expressing green fluorescent protein (GFP). *P < 0.05; **P < 0.01; ***P < 0.001.

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