Fig. 8: Knockdown of tripartite motif-containing protein 21 (TRIM21) promotes proliferation, invasiveness, and migration and inhibits apoptosis of papillary thyroid cancer (PTC) cells. | Cell Death & Disease

Fig. 8: Knockdown of tripartite motif-containing protein 21 (TRIM21) promotes proliferation, invasiveness, and migration and inhibits apoptosis of papillary thyroid cancer (PTC) cells.

From: Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway

Fig. 8

A After TRIM21 knockdown in PTC cells, the expression of TRIM21 was detected by RT-qPCR and Western blotting assays. B After TRIM21 knockdown in PTC cells, cell viability was detected by CCK8 assay at 0, 24, 48, and 72 h, respectively. After TRIM21 knockdown in PTC cells, the proliferation (C), invasion (D), migration (E), and apoptosis (F) of these PTC cells were determined through colony formation assays, Transwell experiment, and flow cytometry respectively. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

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