Fig. 7: Clinical relevance of METTL1, WDR4, and TNF-α in PTC. | Cell Death & Disease

Fig. 7: Clinical relevance of METTL1, WDR4, and TNF-α in PTC.

From: METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-α

Fig. 7

a Representative immunohistochemistry of METTL1 (upper), WDR4 (middle), and TNF-α (lower) proteins in PTC tissues from patients with (n = 14) or without (n = 34) lymph node metastasis. Scale bar = 100 μm (100×) or 25 μm (400×). b Statistical analysis of the histoscore of METTL1 (upper), WDR4 (middle), and TNF-α (lower) proteins in PTC tissues with (n = 14) or without (n = 34) lymph node metastasis. Mann–Whitney U-test, *P < 0.05, ***P < 0.001. c Correlations among METTL1, WDR4 and TNF-α levels in PTC tissues (n = 48). Pearson correlation coefficient test. d Schematic diagram for METTL1 cooperates with WDR4 to drive the proliferation and metastasis of PTC through regulating the translation of TNF-α translation.

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