Fig. 2: HFD-induced obesity promotes the increase of monocytes in vivo, and correlates with peripheral dyslipidemia. | Cell Death & Disease

Fig. 2: HFD-induced obesity promotes the increase of monocytes in vivo, and correlates with peripheral dyslipidemia.

From: Adipocytes regulate monocyte development through the OGT-NEFA-CD36/FABP4 pathway in high-fat diet-induced obesity

Fig. 2: HFD-induced obesity promotes the increase of monocytes in vivo, and correlates with peripheral dyslipidemia.The alternative text for this image may have been generated using AI.

A–E Serum levels of TG, TC, LDL-C, FBG and HDL-C in the underweight, normal weight, and overweight groups in 12 h fasted state. F–K Correlation analysis of serum levels of TG, TC, LDL-C, FBG, NEFA and HDL-C with absolute values of MONO in peripheral blood. L Correlation analysis of serum levels of NEFA with proportions of MONO/WBC in peripheral blood. M Representative images of BAT, iWAT, and eWAT in the ND (n = 5) and HFD (n = 5) groups. N Tissue weights, presented as % of body weight in mice described in (M) (ND group n = 5; HFD group n = 5). O–T Serum levels of TG, TC, GLU, LDL-C, HDL-C and NEFA in the ND (n = 5) and HFD (n = 5) groups in 12 h fasted state. U The change in the proportion of monocytes to WBCs in PB of mice in the HFD (n = 5) group during HFD feeding for 8 weeks. V mRNA levels of PU.1 in HSCs from ND (n = 5) and HFD groups (n = 5). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns not significant.

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