Fig. 4: GSDME deficiency limits the severity of IAV infection.
From: Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection
Gsdme−/− mice and wildtype littermate controls were infected with 104 PFU of HKx31 (H3N2) as a model of severe IAV infection. n = 8 per group. A Mouse weights were recorded daily and presented as mean percent weight change ± SD. *P < 0.05, two-tailed, unpaired Student’s t test. B Clinical signs of disease on a scale of 0–3 were scored daily, as described in the methods. *P < 0.05, two-tailed, unpaired Student’s t test. Results are expressed as mean ± SD. C Survival curves as shown. ***P < 0.001, Mantel–Cox log-rank test.
