Fig. 6: GSDME deficiency limits the production of local and systemic pro-inflammatory cytokines.
From: Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection
Gsdme−/− mice and wildtype littermates were infected with 104 PFU HKx31 IAV. BAL (A-M) and serum (N-S) were collected on days 3 and 5 post-infection. Levels of A IL-1β, B IL-18, C IL-6, D TNF, E CCL2, F IFNɑ, G IFNβ, H IFNγ, I IL-12p70, J IL-10, K IL-1ɑ, L CXCL1, and M CXCL2 in BAL fluid. N/A indicates not assayed. Levels of N IL-6, O TNF, P IFNγ, (Q) CCL2, (R) IL-10, and (S) IL-12p70 in serum. A–S Data determined by cytokine bead array, or ELISA. n = 6, 7, or 8 per group. Data are presented as mean ± SD, with each data point representing an individual animal. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed, unpaired Student’s t test.
