Fig. 6: DMF synergizes with anti-PD-L1 antibodies to inhibit the tumor growth in renal cancer. | Cell Death & Disease

Fig. 6: DMF synergizes with anti-PD-L1 antibodies to inhibit the tumor growth in renal cancer.

From: Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma

Fig. 6

A A schematic representation of the animal experiment process is shown. B Female BALB/c mice underwent treatment with a control, DMF, αPD-L1, or a combination of DMF + αPD-L1. Tumors were subsequently resected from each treatment group as indicated, with n = 6 mice per group. C Tumor growth of RAG cells in female BALB/c mice was determined. Statistical differences were determined by ordinary one-way ANOVA. *P < 0.05, ****P < 0.0001. D The weight of tumors resected from each group of mice that received different treatments as indicated was analyzed. Data represent mean ± SD, n = 6 mice per group. Statistical differences were determined by ordinary one-way ANOVA. **P < 0.01, ***P < 0.001, ****P < 0.0001. E Immunohistochemistry showed CD8+ T cell infiltration and granzyme B expression in the RAG tumor tissues as indicated (scale bars, 20 μm). F Quantifications of images in (E). Data represent mean ± SD from six independent samples of each group. Statistical differences were determined by ordinary one-way ANOVA. ***P < 0.001, ****P < 0.0001.

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