Fig. 6: K350 is sufficient for cGAS activity in autoimmune disease.
From: KDM4B enhances immune surveillance via demethylating cGAS
A Picture and body weight of wild-type (WT), Trex1−/−, and Trex1−/−CgasK350R/K350R littermate mice (left), and wild-type (WT), Trex1−/−, and Trex1−/−CgasK350M/K350M littermate mice (right) (n = 3). B, C Ifnb1 (B) and ISGs (C) expression in hearts of mice of the indicated genotype. D Paraffin-embedded heart tissue sections from mice of the indicated genotype. The top panels are at ×10 and the bottom panels are at ×40 magnification. Data are mean ± SEM for A, unpaired t test. Data are mean ± SEM for B and C, one-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
