Fig. 4: HCQ treatment improved retinal function in Lpr/P23H mice. | Cell Death & Disease

Fig. 4: HCQ treatment improved retinal function in Lpr/P23H mice.

From: Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice

Fig. 4

A Representative immunostaining images of the retina of HCQ Lpr/P23H, Lpr/P23H, and C57 mice at 4 months of age, stained with rhodopsin (RHO in red), m-opsin (green), and DAPI (blue). B Representative scotopic traces (at 0.01, 1, 10, 32, and 64 cd s/m2) and C quantification of amplitudes of scotopic a-wave and b-wave of HCQ treated Lpr/P23H (n = 11), untreated Lpr/P23H mice (n = 10) at 4 months of age. D Representative photopic ERG traces (at 10, 32, and 100 cd s/m2) and E quantification of amplitudes of photopic b-wave of HCQ treated Lpr/P23H and control Lpr/P23H mice at 4 months of age. ns, not significant, *P < 0.05; **P < 0.01; one-tailed Wilcoxon test. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer, IS inner segment, OS outer segment.

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