Fig. 5: In P23H mice, combining HCQ treatment with intravitreal injections of ONL1204 reduced photoreceptor death than HCQ treatment alone. | Cell Death & Disease

Fig. 5: In P23H mice, combining HCQ treatment with intravitreal injections of ONL1204 reduced photoreceptor death than HCQ treatment alone.

From: Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice

Fig. 5

A Quantification of caspase 8 activity in the retina of HCQ + ONL1204 treated and HCQ+ Vehicle-treated eyes of the P23H mice at 1 month of age, normalized to ONL thickness (n = 10, 2 retinas from 2 mice were pooled for each sample). B Representative TUNEL staining images and C quantification of TUNEL-positive cells in the ONL for HCQ + ONL1204 treated and HCQ+ Vehicle-treated P23H eyes at 1 month (n = 6). **P < 0.01; ***P < 0.001, t-test. INL inner nuclear layer, ONL outer nuclear layer.

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