Fig. 6: Combination of HCQ with ONL1204 preserved photoreceptors in the retinas of P23H mice. | Cell Death & Disease

Fig. 6: Combination of HCQ with ONL1204 preserved photoreceptors in the retinas of P23H mice.

From: Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice

Fig. 6

A Representative H&E staining images show preserved ONL thickness (red bar) in the retinas of HCQ + ONL1204-treated eyes at 4 months of age. B Quantification of the thickness of the ONL of the superior and inferior retina measured at both 250 and 500 µm from the optic nerve head by OCT in HCQ + ONL1204 treated eyes and HCQ + CTL vehicle-treated control eyes at the age of 4 months (n = 15). C Representative OCT images of superior (Sup) and inferior (Inf) retina of 4-month-old HCQ + ONL1204 treated eye and HCQ + CTL vehicle-treated fellow eyes. **P < 0.01; ***P < 0.001; ****P < 0.0001, unpaired t-test. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer.

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