Fig. 8: HCQ + ONL1204 treatment preserved visual function in P23H mice. | Cell Death & Disease

Fig. 8: HCQ + ONL1204 treatment preserved visual function in P23H mice.

From: Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice

Fig. 8

A Representative immunostaining images of the inferior retina of HCQ + ONL1204 treated eyes and HCQ+ control vehicle-treated fellow eyes of the P23H mice, at 4 months of age, stained with rhodopsin (red), m-opsin (green), and DAPI (blue). B Representative scotopic traces (at 0.01, 1, 10, 32, and 64 cd s/m2) and C quantification of amplitudes of scotopic a-wave and b-wave of HCQ + ONL1204 treated and HCQ + CTL treated fellow eye at 4 months of age. D Representative photopic ERG traces (at 10, 32, and 100 cd s/m2) and E quantification of amplitudes of photopic b-wave of HCQ + ONL1204 and HCQ + CTL-treated fellow eyes of P23H mice at 4 months of age (n = 8), **P < 0.01; one-tailed Wilcoxon test. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer.

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