Fig. 2: Gene set enrichment analysis and validation of CSC markers in CDH17-silenced cells. | Cell Death & Disease

Fig. 2: Gene set enrichment analysis and validation of CSC markers in CDH17-silenced cells.

From: Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells

Fig. 2: Gene set enrichment analysis and validation of CSC markers in CDH17-silenced cells.

Gene set enrichment analysis (GSEA) using hallmark gene sets from the molecular signature database for the downregulated (A) or upregulated (B) genes in CDH17-silenced (sh60) colon cancer cells. Normalized Enrichment Scores (NES) and normalized p-values are shown inside each panel. Validation of selected targets affected by CDH17 silencing using (C) Western blot and (D) flow cytometry analyses. Below each lane, band quantification relative to control cells is shown. Data are representative of three independent experiments.

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