Fig. 3: OB neurogenesis is lost in TKO mice by 16wpt but is preserved in DKO mice. | Cell Death & Disease

Fig. 3: OB neurogenesis is lost in TKO mice by 16wpt but is preserved in DKO mice.

From: Rb substantially compensates for the double loss of p130 and p107 in adult but not embryonic neural stem cell lineages

Fig. 3

IHC in the granule cell layer -GCL- (A–F”) and the periglomerular layer -GL- (G–L”) showing YFP+ and NeuN+ newborn neurons inside the OB at 4wpt and 16wpt across genotypes. Insets in panels show higher magnification images of the boxed regions in each layer. Quantification of cell counts inside the GCL (M) and GL (N) showing a steady accumulation of newborn neurons inside the OB layers in THC and DKO mice compared with a sharp decline in the level of neurogenesis in TKO brains between 4wpt and 16wpt. Scale bars, 50 µm. Error bars, mean ± SD. Unpaired 2-tailed Student’s t-test; *p < 0.05, **p < 0.01, ***p < 0.001. n = 3 biological replicates.

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