Fig. 4: Loss of OB neurogenesis is due to severe survival defects in TKO mice. | Cell Death & Disease

Fig. 4: Loss of OB neurogenesis is due to severe survival defects in TKO mice.

From: Rb substantially compensates for the double loss of p130 and p107 in adult but not embryonic neural stem cell lineages

Fig. 4

IHC on brain sagittal sections in the aSVZ (A–D”) and rRMS (E–H”) in THC versus TKO mice. Insets show higher magnification images of the boxed regions shown in each region (red; AC-3 staining, and triple staining). Note the massive cell death detected in TKO brains compared with THC at 4wpt and 8wpt. Quantification of cell counts inside of the aSVZ (I) and rRMS (J). TKO mice exhibit extensive cell death in both regions compared with THC and DKO mice. The majority of (YFP + AC-3+) cells co-express DCX in TKO mice, highlighting massive death in neuroblasts. ‡, Triple cell counts were not performed at 16wpt. Scale bars, 50 µm. Error bars, mean ± SD. Unpaired 2-tailed Student’s t-test; *p < 0.05, **p < 0.01, ***p < 0.001. n = 3–4 biological replicates.

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