Fig. 7: Schematic diagram of CENPT mediating GSH synthesis and inhibiting ferroptosis.
From: CENPT prevents renal cell carcinoma against ferroptosis by enhancing the synthesis of glutathione
CENPT interacts with GCLC by competing with GCLM to promote GSH synthesis and inhibit ferroptosis in RCC cells. In turn, GSH increases the expression level of CENPT at transcript level via activation the transcription factor ATF2, forming a CENPT-GCLC-GSH feedback loop that enhances the pro-carcinogenic effect of this axis in RCC cells.
